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inglês
This process is an important step in the synthesis of some non-essential amino acids (amino acids that can be synthesized de novo by the organism).
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In some jurisdictions, a party who loses in a small-claims court is entitled to a trial "de novo" in a court of more general jurisdiction and with more formal procedures.
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Often the de novo pathway is interrupted as a result of chemotherapy drugs such as methotrexate or aminopterin.
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It is believed that tumor cells obtain most part of their requirement for fatty acids by "de novo" synthesis.
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These compounds can be formed by "de novo" synthesis or by modifying a pre-existing pyrrolizidine alkaloid that is consumed from the plant.
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The product phosphoribosyl pyrophosphate acts as an essential component of the purine salvage pathway and the de novo synthesis of purines.
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Bacterial abscesses rarely (if ever) arise "de novo" within the brain, although establishing a cause can be difficult in many cases.
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However, "de novo" resistance to endocrine therapy undermines the efficacy of using competitive inhibitors like tamoxifen.
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The court concluded that... if we were called upon to review the guardianship court's decision "de novo," we would still affirm it.
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This effect may have therapeutical relevance given that the schistosome, as the taenia and the echinococcus (other praziquantel sensitive parasites), is unable to synthesize purines such as adenosine "de novo".
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