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Weitere Studien müssen klären, ob die Beschleunigung der Plaquebildung als therapeutischer Ansatz in Frage kommt.

„Wir hoffen, dass unsere Ergebnisse die Forschungsaktivität in diese Richtung besonders in der Wirkstoffforschung stimulieren“, so Prof. Wanker.

*Small-molecule conversion of toxic oligomers to nontoxic b-sheet–rich amyloid fibrils

www.mdc-berlin.de

Further studies will be necessary to address the question whether the accelerated formation of large plaques can be a therapeutic approach.

“We hope that our findings will stimulate research activities in this direction, especially in drug discovery,” Professor Wanker said.

*Small-molecule conversion of toxic oligomers to nontoxic b-sheet–rich amyloid fibrils

www.mdc-berlin.de

Die zu koordinierenden Teilprojekte waren an verschiedenen Standorten und in unterschiedlichen Forschungsbereichen tätig ..

Für ein effizientes zentrales Projektmanagement des Verbundes und der Technologieplattform wurde zu Projektbeginn in der Arbeitsgruppe Wanker am MDC Berlin ein Koordinationsbüro eingerichtet.

www.ngfn.de

The subprojects that required coordination were active at different locations and in different research areas ..

For an efficient central project management of the IG NeuroNet and the technology platform a management office was established at the MDC Berlin in the group of E.

www.ngfn.de

„ Neuer Wirkmechanismus “

Vor einigen Jahren hatten Prof. Wanker und seine Mitarbeiter entdeckt, dass die Substanz EGCG (Epigallocatechin-3-gallate) in grünem Tee die giftigen Eiweißablagerungen in nichttoxische Ablagerungen umwandelt.

Am Beispiel von Orcein und O4 zeigen die Forscher einen weiteren Mechanismus zur Entgiftung von Eiweißablagerungen.

www.mdc-berlin.de

New Mechanism

A few years ago Professor Wanker and his colleagues discovered that EGCG (Epigallocatechin-3-gallate), a natural chemical compound found in green tea, renders toxic protein assemblies non-toxic.

With orcein and O4 the researchers have now found another mechanism to eliminate small toxic protein aggregates.

www.mdc-berlin.de

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