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Da Tumorstammzellen ohne CXCR4 nicht lebensfähig sind, könnte in Zukunft die zusätzliche Gabe von CXCR4-Hemmstoffen die Wirksamkeit von Tumortherapien bei Nierenzellkarzinompatienten verbessern.

Zudem konnte Gassenmeier in seiner prämierten Arbeit “CXC chemokine receptor 4 is essential for maintenance of renal cell carcinoma-initiating cells and predicts metastasis“ zeigen, dass das Ausmaß der CXCR4-Produktion in Primärtumoren maßgeblich für die Prognose ist, was eine Einschätzung des Risikopotenzials für verschiedene Patienten erlaubt.

www.uni-muenchen.de

Thus, the addition of a CXCR4 inhibitor to current treatment regimes for renal cell carcinoma could in the future markedly improve the effectiveness of therapeutic options available for the condition.

In addition, Gassenmeier has shown that the level of CXCR4 production in the primary tumor is a valuable prognostic marker that allows one to subdivide patients into different risk groups and treat each with the best combination of drugs.

www.uni-muenchen.de

Seine Forschungsergebnisse publizierte Gassenmeier 2013 und 2014 in den Journals „ Stem Cells “ und „ The Journal of Urology “.

Maximilian Gassenmeier wurde 1988 in Erlangen geboren.Er studierte Medizin an der LMU und begann 2011 im Labor für Tumorimmunologie am LIFE-Zentrum des Klinikums der Universität München seine Promotion zum Thema “Identification and characterization of renal cell carcinoma-initiating cells”.

Zurzeit ist er im Rahmen des Praktischen Jahres (PJ) am Departement Innere Medizin des Universitätsspitals Zürich tätig.

www.uni-muenchen.de

Gassenmeier ’s work on CXCR4 appeared in the journals Stem Cells and The Journal of Urology in 2013 and 2014.

Born in Erlangen in 1988, Maximilian Gassenmeier studied Medicine at LMU and began the work for his doctoral thesis on “Identification and characterization of renal cell carcinoma-initiating cells” in 2011 in the Laboratory of Tumor Immunology at the LIFE Center at Munich University Medical Center.

He is currently a junior resident in the Department of Internal Medicine at Zürich University Hospital.

www.uni-muenchen.de

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