Als Auslöser der erst in höherem Alter auftretenden CLL werden genetische Veränderungen angenommen, die die DNA-Reparaturmechanismen und damit auch wichtige Tumorsuppressorgene beeinträchtigen oder ausschalten.
Die Klinische Forschergruppe „ Exploiting defects in the DNA damage response for the treatment of chronic lymphocytic leukemia “ will untersuchen , welche Veränderungen im DNA-Reparatur-Netzwerk auf molekularer Ebene vorliegen , die zu einer chronisch lymphatischen Leukämie führen .
www.dfg.deThe trigger of CLL, which occurs at a higher age, is assumed to be the result of genetic changes that affect or switch off DNA repair mechanisms and thus also important tumour suppressor genes.
The aim of the Clinical Research Unit " Exploiting Defects in the DNA Damage Response for the Treatment of Chronic Lymphocytic Leukemia " is to examine what changes occur in the DNA repair network at the molecular level that lead to chronic lymphocytic leukemia .
www.dfg.deThe trigger of CLL, which occurs at a higher age, is assumed to be the result of genetic changes that affect or switch off DNA repair mechanisms and thus also important tumour suppressor genes.
The aim of the Clinical Research Unit " Exploiting Defects in the DNA Damage Response for the Treatment of Chronic Lymphocytic Leukemia " is to examine what changes occur in the DNA repair network at the molecular level that lead to chronic lymphocytic leukemia .
www.dfg.deAls Auslöser der erst in höherem Alter auftretenden CLL werden genetische Veränderungen angenommen, die die DNA-Reparaturmechanismen und damit auch wichtige Tumorsuppressorgene beeinträchtigen oder ausschalten.
Die Klinische Forschergruppe „ Exploiting defects in the DNA damage response for the treatment of chronic lymphocytic leukemia “ will untersuchen , welche Veränderungen im DNA-Reparatur-Netzwerk auf molekularer Ebene vorliegen , die zu einer chronisch lymphatischen Leukämie führen .
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