Die abgespaltenen Nukleinsäuren wiederum dienen als Signal, das weitere Reparaturmechanismen – oder bei zu großen Schäden den Zelltod – in Gang setzt.
Defekte des MR-Komplexes lösen beim Menschen schwere Erkrankungen aus wie etwa das Nijmegen Breakage Syndrom, das mit erhöhter Strahlenempfindlichkeit einhergeht.
„Trotz der großen Bedeutung des MR-Komplexes war bisher völlig unklar, wie MR als Sensor die vielen heterogenen Brüche und DNA-Enden, die teilweise auch noch durch andere Proteine blockiert sind, erkennen kann“, erzählt Hopfner.
www.cup.uni-muenchen.deThe nucleotides released act as a signal for further steps in repair or, if the damage is extensive, lead to induction of programmed cell death.
In humans, defects in the MR complex lead to serious medical conditions, such as Nijmegen Breakage Syndrome, which is associated with hypersensitivity to radiation.
“Despite its great significance, it was hitherto completely unclear how the MR complex actually recognizes the many different types of breaks at DNA ends, which may also be masked by other proteins,” says Hopfner.
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