Die Gewebeproben von Krebspatienten werden im Labor aufbereitet und das darin enthaltene Erbgut in viele kleine Schnipsel zerstückelt.
Die Lösung wird dann mit sogenannten Microarrays ( DNA Chips ) oder mittels neuartiger Sequenzierverfahren verarbeitet.
„ Am Ende erhält man eine Art Karte des Epigenoms, also sämtlicher biochemischer Markierungen jenseits der eigentlichen DNA-Sequenz “, erklärt Thomas Lengauer.
www.mpg.deThe tissue samples from cancer patients are processed in the laboratory and the genetic material they contain is cut into numerous small snippets.
The solution is then processed using microarrays ( DNA chips ) or using new-generation sequencing processes.
“ Eventually you get a kind of map of the epigenome, which comprises all of the biochemical markings layered on top the actual DNA sequence, ” explains Thomas Lengauer.
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