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Immunhistochemische Untersuchungen verschiedener Gewebe

Xenograft-Modelle mit Zelllinien und humanen disseminierten Tumorzellen mittels verschiedener Applikationen ( subkutan, intrafemoral, mammary fat pad, subrenal )

Detektion und Analyse einzelner disseminierter Tumorzellen im Knochenmark

www.item.fraunhofer.de

Immunohistochemistry

Xenograft models using cell lines and human disseminated cancer cells via different routes of administration ( subcutaneous, intrafemoral, mammary fat pad, subrenal )

Detection and analysis of single disseminated tumor cells in bone marrow

www.item.fraunhofer.de

Fehlt den Epithelzellen des Brustgewebes STAT1, so bilden sich dort vermehrt kleine Inseln aus Krebszellen.

Diese MINs ( für Mammary Intraepithelial Neoplasias ) genannten Krebsinseln entstehen durch entartetes Zellwachstum, sie sind der erste Schritt in der Entwicklung einer Krebserkrankung.

STAT1 ist also ein wichtiger molekularer Schalter, der diesen ersten Schritt der Tumorentstehung wirkungsvoll unterdrücken kann.

www.vetmeduni.ac.at

When the protein is removed from breast cells, there is an increased formation of small cancerous growths within the epithelia, known as mammary intraepithelial neoplasias or MINs.

MINs arise as a result of accelerated cell division within the epithelial cells and are believed to represent a stepping-stone on the way to full-blown cancer.

In other words, removing STAT1 is somehow interfering with a mechanism – presumably involving the transcription factor IRF1, which is known to be under the direct control of STAT1 – for preventing unwanted cell division.

www.vetmeduni.ac.at

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